How Does Medical Marijuana Work For Crohn’s Disease?
Medical marijuana has grown as a treatment for bowel inflammation and cramping painful gastro-intestinal disorders. These disorders include the colitis, Crohn’s disease, and IBS. People also experience cramping, loss of weight, chronic pain , inflammation and diarrhoea with this disease. Legal marijuana is also able to greatly relieve these symptoms.
Crohn’s disease is a chronic inflammatory bowel condition that causes extreme pain. It is not clear why. In very rare cases digestion is adversely affected and fatal. The disease harms the bladder. In the United States there are more than 500,000 individuals with Crohn’s disease. Crohn’s disease is an acceptable condition for use in most states that have licenced medical marijuana.
Crohn’s typical drugs include Imuran, Mesalamin, Steroid, 6 MP, methotrexate and Remicade. Typical drugs are immunosuppressive. Similar symptoms such as nausea, abdominal pain , vomiting, and diarrhoea may result from these care. Steroids can have some harmful effects, including suprarenal dysfunction, ulcers, bone dilution, and glucose sensitivity.
Several experimental trials have shown positive results in gastrointestinal conditions like crohn’s in medical marijuana to alleviate symptoms.
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A research in O’Shaughnessy in 2005 showed that the effects of Crohn’s disease have been significantly supported by cannabis. A pilot study using marijuana in a dozen patients with Crohn’s and patients from the Society of Cannabis Physicians described major changes in the appetite, vomiting, exhaustion, nausea and depression. Every day there have been fewer flares and fewer stools. Patients were also able to decrease the number of drugs required for immunosuppression.
A further research from 2001 called Cannabinoids & the GastrointEScope showed that a variety of GI diseases-including inflammatory sores of the bowels, gastro-sophageal reflux disorders, gastric ulcers, secretory diarrhoea and colon cancer-could probably be treated with cannabinoids in marijuana. Receptors can be located in both the mind and the CB1 receptor GI system. In animals, the analysis showed that agonists delayed gastric emptying and inhibited gastric acid secretion for certain receptors. Generally, in the human brain, CB1 receptors are found.
An Endocrinological Research published in 2006 reveals that the activation of cannabinoid receptors CB2 and CB1 perform biological functions on the gastrointestinal tract.
In various cells, including the GI tube lining, you can find CB2 receptors outside the brain. Cannabinoids which activate the CB2 receptor are present in marijuana-this is thought to reduce inflammation in the GI system, as well as reducing pain and swelling. In cannabis, the beta caryophyllene is another compound that activates the receiver of CB 2.